N-Acetyl Selank Amidate is classified as an anxiolytic and nootropic peptide modified from the original Selank. Researchers amidated and acetylated the peptide for better stability and pharmacokinetics. Although N-Acetyl Selank Amidate has not been well researched for its impacts, it is anticipated to engage with different brain neurotransmitters and neutrophils to produce potential action comparable to Selank.
N-Acetyl Selank Amidate: What Is It?
The nootropic and anxiolytic heptapeptide Selank, which contains the tetrapeptide tuftsin at its N-terminus and a Pro-Gly-Pro fragment at its C-terminus, is supposedly enhanced in Amidate.
The distinct chemical makeup of Selank and N-acetyl Selank Amidate is thought to allow them to pass across the blood-brain barrier (BBB). With the intention to increase stability without sacrificing any of Selank’s possible actions, N-Acetyl Selank Amidate is amidated and acetylated.
In theory, N-Acetyl Selank Amidate may provide the same actions associated with the research compound, Selank, potentially without the impact of increased stress hormone and increased cognitive function due to its structural modifications that may alter the peptide’s pharmacokinetics rather than its pharmacodynamics.
What follows is an explanation of how N-Acetyl Selank Amidate may hypothetically work, based on the research that has attempted to evaluate the properties of Selank:
- Reduced neuronal excitability and anxiety are two possible outcomes of Selank’s potential to upregulate GABA signaling in the CNS.
- The opioid receptor ligand Selank is hypothesized to block the enzymes that hydrolyze enkephalins.
- The metabolic activation of serotonin by Selank may aid in mood control and certain cognitive functions.
- Selank’s nootropic and anxiolytic potential may be amplified due to its possible impacts on neurotransmitters such as dopamine and norepinephrine.
- Additionally, the peptide may promote neuronal survival and resistance against stress by increasing the production of brain-derived neurotrophic factor (BDNF), a neurotrophic factor in the central nervous system.
N-Acetyl Selank Amidate is only accessible for purchase and use in research laboratories.
N-Acetyl Selank Amidate Potential
Next to no scientific research has been published on the acetylated form of N-Acetyl Selank Amidate. Thus, to reference the possible impacts of the improved version, researchers may need to depend on data from Selank investigations to point to N-Acetyl Selank Amidate’s potential.
N-Acetyl Selank Amidate: Cognition and Memory
Research on Selank that has suggested its impacts on cognition and memory might be consulted for the possible nootropic impacts of N-Acetyl Selank Amidate:
The impacts of combining Selank alongside a long-acting benzodiazepine as a control compound were studied in an experiment. The peptide’s cognitive-enhancing potential appeared to have mitigated the risk of the control compound’s negative effects. Selank has been hypothesized to mitigate the memory recall failure and physiological decline associated with long-term benzodiazepine exposure.
In an experiment involving rat models of neurological disorders, a nootropic control compound was compared against Selank. Over three days, the action of Selank on the rats’ learning ability seemed to have increased to the point where they were more effective than the control.
Another rat study suggests that Selank, possibly due to its alleged serotonin-enhancing potential, may stabilize memory formation in test animals, reportedly for up to one-month duration.
N-Acetyl Selank Amidate and Neurotoxicity
Experimental and preclinical studies suggest that Selank may potentially have neuroprotective properties that may reduce withdrawal symptoms after addiction patterns have been established. N-Acetyl Selank Amidate’s potential may be better understood in light of these findings:
Research indicates that Selank may have successfully mitigated the acute 48-hour alcohol withdrawal symptoms in rats that had been acclimated to 10% ethanol for 24 weeks. In particular, it was suggested that a single exposure to Selank may have reduced anxiety caused by ethanol and mechanical allodynia without changing the amount of ethanol consumed, suggesting that it may help with alcohol withdrawal.
In addition to mitigating the neurotoxic actions seen in the rat models of long-term alcohol exposure, the same study suggested that Selank appeared to have protected neurons. According to the researchers, this might be because rats given Selank seemed to have higher levels of BDNF in their brains.
The rat morphine withdrawal model also suggested that Selank may have considerably reduced withdrawal symptoms. A concentration was hypothesized to reduce the total withdrawal syndrome index by about 40%, alleviate several symptoms, and increase tactile sensitivity nine-fold. Although Selank’s possible impacts did not seem as strong as the control substance, it was theorized to nevertheless potentially be able to reduce the withdrawal symptoms of morphine in rats that were dependent on opiates.
N-Acetyl Selank Amidate: Stress and Anxiety
It is crucial to keep in mind that Selank has been widely studied in Russia within the context of generalized anxiety disorder (GAD) while using the available data on the compound.
When considering the possible anxiolytic and anti-stress impacts of N-Acetyl Selank Amidate, it is helpful to refer to the two most prominent Selank studies:
A research model study comparing Selank to an anxiolytic control compound suggested that the former may have been more active in alleviating GAD symptoms. According to the results, Selank appeared to be potentially just as effective as the control compound in reducing anxiety following daily exposure for a set duration.
The impacts of a 14-day course of Selank were evaluated in another experimental study on anxiety disorders, researchers indicated that Selank may have considerably reduced symptoms, continuing even one week following the exposure. As the research authors noted, Selank may potentially have moderate impacts in improving cognitive function.
N-Acetyl Selank Amidate vs. Selank Peptide
The key distinctions between N-Acetyl Selank Amidate and ordinary Selank are summarized below.
- Pharmacokinetics and Stability: Selank has been hypothesized to cross the blood-brain barrier (BBB). N-Acetyl Selank Amidate is believed to improve stability by enhancing its half-life and bioavailability through acetylation and amidation, shielding the peptide’s N- and C-terminal groups from enzymatic breakdown.
- Possible nootropic, neuroprotective, and immunomodulatory impacts of the peptide are currently the subject of ongoing research. Conversely, N-Acetyl Selank Amidate is only accessible as a research compound and has not been the subject of any study.
- Positive Outcomes: Selank has been hypothesized reduce anxiety via seratonin and dopamine regulation. Data suggests that N-Acetyl Selank Amidate may have comparable potential, because of its improved pharmacokinetics; however, this is purely conjecture due to lack of study.
You can buy peptides online if you are a researcher interested in further studying the potential of N-Acetyl Selank Amidate and Selank peptide.
